Meta menu:

From here, you can access the Emergencies page, Contact Us page, Accessibility Settings, Language Selection, and Search page.

Open Menu
Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

Z1 - Prof. Dr. Christian Spahn / Dr. Thorsten Mielke

You are here:

Z1: Molecular electron microscopy

This project aims to facilitate structural analysis of functional modules within the consortium using three-dimensional (3D) electron/cryo-electron microscopy (cryo-EM). This methodology has as emerged as a key technology in structural biology to study the structure of large macromolecular assemblies and molecular machines. The development of dedicated transmission electron microscopes (TEMs) together with advanced image processing methods such as multiparticle refinement strategies allows to process heterogeneous samples with ever improving resolution. Especially the introduction of new direct electron detector (DED) systems is currently revolutionizing the cryo-EM field and has pushed the attainable resolution of single particle analysis into the near-atomic range.

Selected Publications