The central project TP Z1 (Spahn/ Mielke) shall facilitate the structural analysis of functional modules within the SFB consortium using cryo-EM in combination with the socalled single particle approach.

Cryo-EM has emerged as a key technology in structural biology beside X-ray crystallography and NMR spectroscopy and represents the ideal tool for structure determination of large macromolecular assemblies and molecular machines at intermediate resolution.

Z1: Molecular electron microscopy