
D8 - Prof. Dr. Dr. h.c. Edda Klipp
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D8: Spatial modeling of gradient sensing exemplified for the yeast pheromone response
Yeast cells mate using pheromone secretion and sensing and directed protrusion formation. Employing a combination of fluorescence and atomic force microscopy with spatiotemporal mathematical modeling, we will investigate the role of functional modules in three types of processes: i) pattern formation of pheromones, ii) implementation of stable spatial cell response, and iii) induction and mechanics of cell shape change. On top, we study principles of mutual information exchange among the mating cells.
Selected Publications
- Authors:Goldenbogen B, Giese W, Hemmen M, Uhlendorf J, Herrmann A, Klipp E
Journal:Open Biol Year:2016; Volume:6Issue:(9):Pages:pii: 160136. doi: 10.1098/rsob.160136.
Title:Dynamics of cell wall elasticity pattern shapes the cell during yeast mating morphogenesis - Authors:Giese W, Eigel M, Westerheide S, Engwer C, Klipp E
Journal:Phys Biol Year:2015; Volume:12Issue:(6):Pages:066014. doi: 10.1088/1478-3975/12/6/066014.
Title:Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models - Authors:Diener C, Schreiber G, Giese W, Del Rio, G, Schroeder, A, Klipp E
Journal:PLoS Comput Biol Year:2014; Volume:10Issue:(6):Pages:e1003690.
Title:Yeast mating and image-based quantification of spatial pattern formation - Authors:Rodriguez Plaza JG, Morales-Nava R, Diener C, Schreiber G, Gonzalez ZD, Lara Ortiz MT, Ortega Blake I, Pantoja O, Volkmer R, Klipp E, Herrmann A, Del Rio G
Journal:J Biol Chem Year:2014; Volume:289Issue:(21):Pages:14448-57.
Title:Cell Penetrating Peptides and Cationic Antibacterial Peptides: two sides of the same coin - Authors:Schreiber G, Barberis M, Scolari S, Klaus C, Herrmann A, Klipp E
Journal:FASEB J Year:2012; Volume:26Issue:(2):Pages:546-54.
Title:Unraveling interactions of cell cycle-regulating proteins Sic1 and B-type cyclins in living yeast cells: a FLIM-FRET approach - Authors:Barberis M, Beck C, Amoussouvi A, Schreiber G, Diener C, Herrmann A, Klipp E
Journal:Mol Biosyst Year:2011; Volume:7Issue:(10):Pages:2804-12.
Title:A low number of SIC1 mRNA molecules ensures a low noise level in cell cycle progression of budding yeast