
D1 - Dr. Martin Heck / Prof. Dr. Klaus Peter Hofmann
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D1: The regeneration-module in photoreceptor cells
In retinal rods the receptor rhodopsin and visual arrestin are at the interlink between three modular functions, namely, G protein coupled signaling, receptor regeneration and translocation of proteins. We want to study how the channeling of the retinal ligand during rhodopsin regeneration works. Main goals are the characterization of the retinal entrance and exit routes and the role of protein flexibility in retinal channeling. We also want to explore the interplay between retinal release and arrestin binding, in order to understand how arrestin protects the rod cell from toxic levels of all-trans-retinal
Selected Publications
- Authors:Sommer, ME, Hofmann, KP and Heck, M
Journal:Handb Exp Pharmacol Year:2014; Volume:219:Pages:101-16.
Title:Not just signal shut-off: the protective role of arrestin-1 in rod cells - Authors:Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME
Journal:Nature Year:2013; Volume:497Issue:(7447):Pages:142-6.
Title:Crystal structure of pre-activated arrestin p44 - Authors:Elgeti M, Rose AS, Bartl FJ, Hildebrand PW, Hofmann KP, Heck M
Journal:J Am Chem Soc Year:2013; Volume:21Issue:(135):Pages:12305-12.
Title:Precision vs Flexibility in GPCR signaling - Authors:Park, JH, Morizumi, T, Li, Y, Hong, JE, Pai, EF, Hofmann, KP, Choe, HW and Ernst, OP
Journal:Angew Chem Int Ed Engl Year:2013; Volume:52Issue:(42):Pages:11021-4.
Title:Opsin, a structural model for olfactory receptors? - Authors:Sommer M.E., Hofmann K.P., Heck M.
Journal:Nature Communications Year:2012; Volume:3:Pages:1273.
Title:Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin - Authors:Piechnick, R., Ritter E., Hildebrand, P.W., Ernst, O.P., Scheerer, P., Hofmann, K.P., Heck, M.
Journal:Proc Natl Acad Sci USA Year:2012; Volume:109Issue:(14):Pages:5247-5252.
Title:Effect of channel mutations on the uptake and release of the retinal ligand in opsin - Authors:Elgeti, M., Kazmin, R., Heck,M., Morizumi, T., Ritter, E., Scheerer, P., Ernst, O.P., Siebert, F., Hofmann, K.P., Bartl, F.J.
Journal: J Am Chem Soc Year:2011; Volume:133Issue:(18):Pages:7159-65.
Title:Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin - Authors:Choe, H. W., Kim, Y. J., Park, J. H., Morizumi, T., Pai, E. F., Krauß, N., Hofmann, K. P., Scheerer, P., Ernst, O. P.
Journal:Nature Year:2011; Volume:471Issue:(7340):Pages:651-5.
Title:Crystal structure of metarhodopsin II - Authors:Sommer, M.E. Hofmann, K.P. & Heck, M.
Journal:J Biol Chem Year:2011; Volume:286:Pages:7359-7369.
Title:Arrestin-rhodopsin binding stoichiometry in isolated rod outer segment membranes depends on the percentage of activated receptors - Authors:Piechnick, R., Heck, M., Sommer, M.E.
Journal:Biochemistry Year:2011; Volume:50Issue:(33):Pages:7168-76.
Title:Alkylated hydroxylamine derivatives eliminate peripheral retinylidene Schiff bases but cannot enter the retinal binding pocket of light-activated rhodopsin