
C9 - Prof. Dr. Stephan Sigrist
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C9: Closing the cycle: Sub-modules in synaptic vesicle membrane targeting, fusion and endocytosis
For synaptic transmission, a sequence of interconnected functional modules obviously organizes synaptic vesicle exo- and endocytosis. Using highly accessible Drosophila neuromuscular synapses, we seek to investigate these coupling processes in the intact living animal. Central to the project is a flash-freeze approach which allows for rapidly capturing ultrastructure after light induced stimulation. We thus hope to contribute to a deeper understanding of how functional sub-modules are coupled for efficient neurotransmission.
Project-Related Publications
- Authors:Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt, BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C
Journal:Proc Natl Acad Sci U S A. Year:2016; Volume:113Issue:(41):Pages:11615-11620. Epub 2016 Sep 26.
Title:RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses - Authors:Sigrist SJ, Petzoldt AG
Journal:Nature Year:2016; Volume:536Issue:(7615):Pages:151-2. Epub 2016 Jul 27.
Title:Neuroscience: Nanocolumns at the heart of the synapse - Authors:Petzoldt AG, Lützkendorf J, Sigrist SJ
Journal:Neurobiol Year:2016; Volume:39:Pages:69-76. doi: 10.1016/j.conb.2016.04.009. Epub 2016 Apr 2.
Title:Mechanisms controlling assembly and plasticity of presynaptic active zone scaffolds - Authors:Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ
Journal:PLoS Biol Year:2016; Volume:14Issue:(9):Pages:e1002563. doi: 10.1371/journal.pbio.1002563. eCollection 2016 Sep.
Title:Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release - Authors:Klemz R, Reischl S, Wallach T, Witte N, Jürchott K, Klemz S, Lang V, Lorenzen S, Knauer M, Heidenreich S, Xu M, Ripperger JA, Schupp M, Stanewsky R, Kramer A
Journal:Nat Struct Mol Biol Year:2016; Volume:24Issue:(1):Pages:15-22. doi: 10.1038/nsmb.3331. Epub 2016 Nov 28.
Title:Reciprocal regulation of carbon monoxide metabolism and the circadian clock - Authors:Hallermann S, Kittel RJ, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M.
Journal:J Neurosci Year:2010; Volume:30Issue:(43):Pages:14340-5.
Title:Naked dense bodies provoke depression - Authors:Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ.
Journal:Science Year:2011; Volume:334Issue:(6062):Pages:1565-9.
Title:RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release - Authors:Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ
Journal:J Cell Biol Year:2013; Volume:202Issue:(4):Pages:667-83.
Title:The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles - Authors:Müller M, Liu KS, Sigrist SJ, Davis GW.
Journal:J Neurosci Year:2012; Volume:32Issue:(47):Pages:16574-85.
Title:RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool - Authors:Owald D, Fouquet W, Schmidt M, Wichmann C, Mertel S, Depner H, Christiansen F, Zube C, Quentin C, Körner J, Urlaub H, Mechtler K, Sigrist SJ
Journal:J Cell Biol Year:2010; Volume:188Issue:(4):Pages:565-79.
Title:A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila - Authors:Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ
Journal:Nat Neurosci Year:2012; Volume:15Issue:(9):Pages:1219-26.
Title:Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic as-sembly