
C8 - Prof. Dr. Volker Haucke
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C8: Functional organization and dynamics of PI kinase-based modules for protein sorting at endosomal membranes
Endosomes function in the uptake, recycling, and degradation of nutrients, receptors, and cell signaling molecules. Previously, we have characterized phosphatidylinositol (PI) 4-kinase type II-based protein modules at endosomes that differentially regulate Wnt signaling. During the forthcoming funding period we will dissect the molecular basis underlying complex formation between PI3KC2β with Raptor and HOPS and of PI4KIIα/β and exocyst. We will analyze how these PI kinase modules are organized in time and space, how they contribute to endolysosomal membrane homeostasis, and how they regulate cell signaling.
Selected Publications
- Authors:Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V.
Journal:Nature Year:2016; Volume:529Issue:(7586):Pages:408-12. doi: 10.1038/nature16516.
Title:A phosphoinositide conversion mechanism for exit from endosomes - Authors:Podufall, J, Tian, R, Knoche, E, Puchkov, D, Walter, AM, Rosa, S, Quentin, C, Vukoja, A, Jung, N, Lampe, A, Wichmann, C, Böhme, M, Depner, H, Zhang, YQ, Schmoranzer, J, Si-grist, SJ*, Haucke, V
Journal:Cell Rep Year:2014; Volume:7Issue:(5):Pages:1417-25.
Title:A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling - Authors:Franco, I, Gulluni, F, Campa, CC, Costa, C, Margaria, P, Ciraolo, E, Martini, M, Monteyne, D, De Luca, D, Germena, G, Posor, Y, Maffucci, T, Marengo, S, Haucke, V, Falasca, M, Perez-Morga, D, Boletta, A, Merlo, GR, Hirsch, E
Journal:Dev Cell Year:2014; Volume:28Issue:(6):Pages:647-58.
Title:PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function - Authors:Wieffer, M., Cibrián Uhalte, E., Posor, Y., Otten, C., Branz, K., Schütz, I., Mössinger, J., Schu, P., Abdelilah-Seyfried, S., Krauß, M., Haucke, V
Journal:Curr Biol Year:2013; Volume:23Issue:(21):Pages:2185-90.
Title:PI4K2b/ AP-1-based TGN-endosomal sorting regulates Wnt signaling - Authors:Posor, Y., Eichhorn-Grünig, M., Puchkov, D., Schöneberg, J., Ullrich, A., Lampe, A., Müller, R., Zarbakhsh, Gulluni, F., Hirsch, E., Krauss, M., Schultz, C., Noe, F., Haucke, V
Journal:Nature Year:2013; Volume:499Issue:(7457):Pages:233-237.
Title:Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate - Authors:Faelber, K., Held, M., Gao, S., Posor, Y., Haucke, V., Noé, F., Daumke, O
Journal:Structure Year:2012; Volume:20Issue:(10):Pages:1621-1628.
Title:Structural insights into dynamin-mediated membrane fission - Authors:Wieffer, M., Haucke, V., Krauss, M
Journal:Meth Cell Biol Year:2012; Volume:108:Pages:209-25 .
Title:Regulation of phosphoinositide metabolizing enzymes by clathrin coat proteins - Authors:Mössinger, J., Wieffer, M., Krause, E., Freund, C., Gerth, F., Krauss, M., Haucke, V.
Journal:EMBO Rep Year:2012; Volume:13Issue:(12):Pages:1087-94.
Title:Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch - Authors:Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noé, F., Daumke, O.
Journal:Nature Year:2011; Volume:477
Title:Crystal structure of nucleotide-free dynamin - Authors:Seifert, W., Kühnisch, J., Maritzen, T., Horn, D., Haucke, V., Hennies, H.C.
Journal:J Biol Chem Year:2011; Volume:286Issue:(43):Pages:37665-75.
Title:Cohen syndrome associated protein COH1 is a novel giant Golgi matrix protein required for Golgi integrity