
C7 - Prof. Dr. Oliver Daumke
You are here:
C7: Structural and functional analysis of the dynamin module
Dynamin oligomerizes around the neck of clathrin-coated vesicles and induces membrane scission in response to nucleotide hydrolysis. Based on the crystal structure of dynamin, we proposed a reversible and flexible assembly of the dynamin helix. In the coming period, we will investigate the molecular mechanisms of the nucleotide-driven mechano-chemical function of the dynamin, the principles of membrane recruitment of dynamin by the BAR-domain containing protein SNX9, and the structural changes in dynamin accompanying membrane recruitment and oligomerization (together with B7, C8, D7).
Selected Publications
- Authors:Shah, C, Hegde, BG, Morén, B, Behrmann, E, Mielke, T, Moenke, G, Spahn, CM, Lundmark, R, Daumke, O*, Langen, R
Journal:Structure Year:2014; Volume:22Issue:(3):Pages:409-20.
Title:Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2 - Authors:Fröhlich C., Grabiger S., Schwefel D., Faelber K., Rosenbaum E., Mears J., Rocks O., Daumke O
Journal:EMBO J Year:2013; Volume:32Issue:(9):Pages:1280-92.
Title:Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein - Authors:Morén B., Shah C., Howes M.T., Schieber N.L., McMahon H.T., Parton R.G., Daumke O., Lundmark R
Journal:Mol Biol Cell Year:2012; Volume:23Issue:(7):Pages:1316-29.
Title:EHD2 regulates caveola dynamics via ATP-driven targeting and oligomerization - Authors:Faelber, K., Held, M. Gao, S., Haucke, V. Noe, F., Daumke, O.
Journal:Structure Year:2012; Volume:20:Pages:1621-1628.
Title:Structural insights into dynamin-mediated membrane fission - Authors:Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noé, F., Daumke, O.
Journal:Nature Year:2011; Volume:477:Pages:556 - 60.
Title:Crystal structure of nucleotide-free dynamin - Authors:Gao, S., von der Malsburg, A., Dick, A., Faelber,, K., Schröder G.F., Haller,, O., Kochs G., Daumke, O.
Journal:Immunity Year:2011; Volume:35Issue:(4):Pages:514-25.
Title:Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function