C5 - Prof. Dr. Dr. Thomas J. Jentsch
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C5: Modules involved in endosomal/lysosomal ion homeostasis and function
Results from our studies focusing on vesicular CLC anion/proton exchangers that were predicted to provide an electrical shunt for the H+-ATPase (responsible for vesicle acidification), indicate much more complex and diverse roles of transporters in this functional module. We therefore aim at analyzing many different vesicular transporters in combination by use of sophisticated mouse models and cell culture systems applying newly available techniques (CRISPR-Cas system). Moreover the role of ClC 7 (lysosomal anion transporter)/kinesin-2-interactions in exocytosis of lysosomes will be investigated.
Selected Publications
- Authors:Weinert, S, Jabs, S, Hohensee, S, Chan, WL, Kornak, U, Jentsch, TJ
Journal:EMBO Rep Year:2014; Volume:15Issue:(7):Pages:784-91.
Title:Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions - Authors:Supanchart, C, Wartosch, L, Schlack, C, Kühnisch, J, Giehl, M, Felsenberg, D, Fuhrmann, JC, de Vernejoul, MC, Jentsch, TJ, Kornak, U
Journal:Bone Year:2014; Volume:58:Pages:92-102.
Title:ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion - Authors:Sartelet, A, Stauber, T, Coppieters, W, Ludwig, CF, Fasquelle, C, Druet, T, Zhang, Z, Ahariz, N, Cambisano, N, Jentsch, TJ*, Charlier, C
Journal:Disease Models & Mech Year:2014; Volume:7Issue:(11):Pages:119-128.
Title:A missense mutation accelerating the gating of the lysosomal Cl–/H+-exchanger ClC 7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle - Authors:Barvencik, F, Kurth, I, Koehne, T, Stauber, T, Zustin, J, Tsiakas, K, Ludwig, C F, Beil, T, Pest-ka, JM, Hahn, M, Santer, R, Supanchart, C, Kornak, U, Del Fattore, A, Jentsch, TJ, Teti, A, Schulz, A, Schinke, T, Amling, M
Journal:J Bone Min Res Year:2014; Volume:29Issue:(4):Pages:982-91.
Title:CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals - Authors:Ludwig, CF, Ullrich, F, Leisle, L, Stauber, T, Jentsch, TJ
Journal:J Biol Chem Year:2013; Volume:288Issue:(40):Pages:28611-9.
Title:Common gating of both CLC subunits underlies voltage-dependent activation of the 2Cl–/H+-exchanger ClC-7/Ostm1 - Authors:Hennings, JC, Picard, N, Huebner, AK, Stauber, T, Maier, H, Brown, D, Jentsch, TJ, Vargas-Poussou, R, Eladari, D, Hübner, CA
Journal:EMBO Mol Med Year:2012; Volume:4Issue:(10):Pages:1057-1071.
Title:A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule - Authors:Leisle, L., Ludwig, C.F., Wagner, F.A., Jentsch, T.J., Stauber, T.
Journal:EMBO J Year:2011; Volume:30Issue:(11):Pages:2140-2152.
Title:ClC-7 is a slowly voltage-gated 2Cl-/H+-exchanger and requires Ostm1 for transport activity