B5 - Prof. Dr. Thomas Sommer
You are here:
B5: Substrate recognition by the HRD-ubiquitin ligase
One of the best-studied ubiquitin ligases involved in protein quality control is the HMG-CoA reductase degradation-(HRD-) ligase. It is embedded in the endoplasmic reticulum (ER) membrane and constitutes the central component of a process termed ER-Associated Protein Degradation (ERAD). We want to investigate the interaction of the main components of this Module with misfolded client proteins and with the folding machinery of the ER. Besides biochemical in vitro studies and yeast genetics, this includes cryoEM and a CLMS approach.
Selected Publications
- Authors:Weber A, Cohen I, Popp O, Dittmar G, Reiss Y, Sommer T, Ravid T, Jarosch E
Journal:Mol Cell Year:2016; Volume:63Issue:(5):Pages:827-39. doi: 10.1016/j.molcel.2016.07.020. Epub 2016 Aug 25.
Title:Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase - Authors:Weber A, Cohen I, Popp O, Dittmar G, Reiss Y, Sommer T, Ravid T, Jarosch E
Journal:Mol Cell Year:2016; Volume:63Issue:(5):Pages:827-39. doi: 10.1016/j.molcel.2016.07.020. Epub 2016 Aug 25.
Title:Sequential poly-ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase - Authors:von Delbrück M, Kniss A, Rogov VV, Pluska L, Bagola K, Löhr F, Güntert P, Sommer T, Dötsch V
Journal:Mol Cell Year:2016; Volume:62Issue:(6):Pages:918-928. doi: 10.1016/j.molcel.2016.04.031. Epub 2016 Jun 2.
Title:The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation - Authors:Denzel, MS, Storm, NJ, Gutschmidt, A, Baddi, R, Hinze, Y, Jarosch, E, Sommer, T, Hoppe, T, and Antebi, A
Journal:Cell Year:2014; Volume:156Issue:(6):Pages:1167-78.
Title:Hexosamine pathway metabolites enhance protein quality control and prolong life - Authors:Mehnert, M., Sommer, T., and Jarosch, E.
Journal:Nature Cell Biol Year:2014; Volume:16Issue:(1):Pages:77-86.
Title:Der1 promotes movement of malfolded proteins through the endoplasmic reticulum membrane - Authors:Amm, I., Sommer T., Tand Wolf, D.H.
Journal: Biochem Biophys Acta Year:2013; Volume:13:Pages:S0167-4889.
Title:Protein quality control and elimination ofprotein waste: The role of the ubiquitin-proteasome system - Authors:Bagola, K., von Delbrück, M., Dittmar, G., Scheffner, M., Ziv, I., Glickman, M. H., Ciechanover, A., and Sommer, T
Journal:Mol Cell Year:2013; Volume:50Issue:(4):Pages:528-539.
Title:Ubiquitin Binding by a CUE Domain Regulates Ubiquitin Chain Formation by ERAD E3 Ligases - Authors:Hampton, RY, and Sommer, T
Journal:Cur Opin Cell Biol Year:2012; Volume:24Issue:(4):Pages:460-6.
Title:Finding the will and the way of ERAD substrate retrotranslocation - Authors:Hanna J., Schütz A, Zimmermann F., Behlke J. Sommer T., Heinemann U.
Journal: J Biol Chem Year:2012; Volume:287:Pages:8633-40.
Title:Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex - Authors:Hampton, R.Y., and Sommer, T.
Journal:Curr Opin Cell Biol Year:2012; Volume:4:Pages:460-466.
Title:Finding the will and the way of ERAD substrate retrotranslocation