Project Area B
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Project Area B: Control Of Conformation And Degradation Of Proteins
Project area B comprises projects that deal with the processing of proteins. As in area A, processes are based on large protein complexes, which undergo dynamic changes in their organisation. In the last funding period first insight was obtained how the specific biological task (protein processing vs. polynucleotide processing in areas B and A, respectively) is reflected by the modular properties. Representative functional modules (chaperones und proteasomes) will be investigated using biochemical, biophysical and structural methods.
Links to Subprojects
B1: Functional and Structural Characterization of Heterotetrameric p97/ASPL complexes
B3: Regulation of proteasome modules
B5: Substrate recognition by the HRD-ubiquitin ligase
B6: Structural elucidation of the GPCR allosteric machine
B7: Structural investigations of modules involved in protein homeostasis
B8: Identification and characterization of a novel metazoan disaggregase module