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Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

A6 - Prof. Dr. Juri Rappsilber

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A6: Structural basis of translation control in eukaryotic 80S ribo-somes by phosphorylation of eS6

As part of the SFB 740 we aim to determine the mechanism by which eS6 phosphorylation influences target-mRNA selection of ribosomes. As further reaching hypothesis we will probe if and how translation is governed by eS6-tail modification patterns (or a simple on/off mechanism), i.e. if there is a ribosomal equivalent to CTD control of transcription or the histone code hypothesis. This would highlight a similarity of regulation between translation and transcription and have huge impact on our understanding of translational control. Moreover, with quantitative cross-linking/mass spectrometry (CLMS) and high-resolution CLMS we introduce technologies to protein assemblies that will allow probing a broad range of mechanistic questions in other research projects of this consortium, specifically Project A4, M. Wahl, Project B5, T. Sommer and Project C7, O. Daumke.

Project-Related Publications