A3 - Prof. Dr. Christian Spahn

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A3: Structure and dynamics of eukaryotic 80S ribosomes during the elongation phase of protein synthesis

In project A3 the ribosomal elongation cycle in eukaryotes will be structurally analyzed using high-resolution single-particle cryo-EM. The ribosome exemplifies functional modules that are organized as macromolecular machines.  Structural dynamics governed by a tuneable energy landscape facilitates ribosomal function. To obtain the structural foundation of the eukaryotic ribosomal elongation cycles at the molecular level in vitro assembled ribosomal complexes as well as ex vivo derived polysomes will be investigated. Moreover, this will reveal some general principles about the inner workings of macromolecular machines.

Selected publications