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First Funding Period (2007 - 2010)

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First Funding Period (2007 - 2010)

Subproject Topic Project Investigators
A1 Dynamics of genome duplication machines Dr. M. Cristina Cardoso
A3 Structure and Dynamics of Eukaryotic 80S Ribosomes during the Elongation Phase of Protein Synthesis Prof. Dr. Christian M. T. Spahn
A4 The sub-module for spliceosome catalytic activation and disassembly Prof. Dr. Markus Wahl
B1 Functional analyses of VCP/p97 containing protein complexes involved in protein folding and degradation Dr. Annett Böddrich, Prof. Dr. Erich Wanker
B2 Structural characterization of chaperone modulated protein aggregation in S. cervisiae Prof. Dr. Bernd Reif
B3 The modular process of proteasome assembly Dr. Elke Beate Krüger, Prof. Dr. Peter-M. Kloetzel
B4 Structural and functional characterization of complex protein modules involved in regulation of proteasomal activity Prof. Dr. Michael Groll
C1 Modular organisation of vesicle tethering to membranes: Analysis of structural features and regulation by protein palmitoylation Prof. Dr. Udo Heinemann
C3 Specific recruitment of viral components and assembly of enveloped viruses Prof. Dr. Andreas Herrmann, PD Dr. Michael Veit
C4 Modular assembly, plasma membrane targeting and regulation of KCNQ (Kv7) K+ channels Prof. Dr. Thomas Friedrich
C5 Protein modules involved in vesicular acidification and trafficking: Focus on ClC-6 Prof. Dr. Dr. Thomas J. Jentsch
C6 The Arf GTPase module in vesicle formation: coordination of coat recruitment and membrane bending with ArfGAP activity Volker Haucke Ph.D.
C7 Assembly and integration of an EHD2 submodule involved in membrane remodelling Prof. Dr. Oliver Daumke
D1 The regeneration module in photoreceptor cells Dr. Martin Heck, Prof. Dr. Klaus-Peter Hofmann
D2 The negative feedback module of the mammalian circadian oscillator: functional impact of phosphorylation Prof. Dr. Achim Kramer
D3 Characterization of the enzyme/substrate submodule and molecular recognition in the g-secretase complex Prof. Dr. Robert Bittl, Prof. Dr. Gerd Multhaup
D4 Regulatory phosphorylation of scaffolding proteins of the inside-out-signaling complex Dr. Christian Freund
D5 The role of rhodopsin opligomers in the amplifier submodule of retinal rods PD Dr. Oliver P. Ernst, Prof. Dr. Klaus-Peter Hofmann
Z1 Molecular electron microscopy and electron tomography Dr. Thorsten Mielke, Prof. Dr. Christian M. T. Spahn